Does she only want one tier in Spice? Are you sure she doesn't want the whole cake in spice? I never thought of it as a holiday flavor myself... I believe my high school graduation cake was spice...
As for what would go good with it... if she wants each tier to be different, I think it particularly wouldn't matter too much since at a wedding most people probably won't be eating each tier together...
You could do Carrot...
You could do a Chocolate with a bit of Hot Pepper...
You could do plain Vanilla even...
You could always do a Marbled Vanilla & Spice layer...
You could also do a plain spice layer, and variations of spice layers like carrot, pumpkin, gingerbread, apple, currant, etc...
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