I use sour cream with box mix to make a really moist cake... so I'd say yes for scratch too...
Yes, check out the famous WASC on this site (theres great variations if you are into cake mix extender recipes). Scratch cakes are great too with sour cream.
Here's the expanded flavors version of the WASC recipe:
http://tinyurl.com/2cu8s4
If you prefer to make scratch sour cream cakes:
http://forum.cakecentral.com/cake-decorating-ftopict-132261-.html
CC recommended scratch cake recipes:
http://forum.cakecentral.com/cake-decorating-ftopicp-3904583-.html
7 Professional Secrets to Baking a Great Cake:
http://tinyurl.com/6mc72d
HTH
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