Do you allow pick up of wedding cakes, and if so, how do you handle it when clients are late?
I would not allow the pick up of a wedding cake personally. Too much can happen between your door and the reception that they will invariably put back on you...even if you have a clause in your contract that addresses this. Of course if it's only 1 or 2 tiers...or just a sheet cake, then it would be easier for someone to transport, but if you're talking 3 or more tiers, I wouldn't allow it.
I hope the cake is paid for. If you are waiting for someone to come pick up a paid-for cake, I imagine someone will show up. If it's not paid for, then who knows. I'd start calling whoever is supposed to come get it and find out what's going on.
I do allow customers to pick up any cake that is not tiered provided it is paid in advance.
Anything that is stacked I don't allow, I can only imgine the potential for disaster. 
I allow pick-ups of up to 2 tier cakes but never anything more like a 3 tier wedding cake. Flowers can get damaged once they leave here. Ppl other than cake decorators don't know how to store cakes when they collect them. I have seen people put boxes of cupcakes in a hot trunk. Imagine that. I have to tell them to keep them in the car with ac. Also, car seats are slanted and most ppl WILL rest a cake in the box on that slanted angle and expect nothing to go wrong.
@flossgrl, I do allow pick-ups, but only during a given timeframe on Saturday mornings between 7:30 and 11:00. I make sure they understand I am leaving for wedding cake deliveries at 11:30. If they aren't there, too bad, so sad.
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