the ganache I use is only chocolate and heavy cream. the truffle recipe has cream cheese and powdered sugar in it. I have only used the ganache to drizzle on a cake, haven't tried it as filling. I love the truffle filling, I think the cream cheese adds a nice flavor to it. hope this helps. 
My truffle filling has cream cheese in it as well. It is VERY different from ganache. I like the texture of a set ganache. Truffle filling is rather thick.
Well i guess it depends on how you define truffles. European Truffles are simply candies made from chocolate and cream. So technically it is a ganache that has been allowed to set. I use the same recipe ganache as filling and frosting but when I use it as filling, I call it chocolate truffle filling. Sounds more decadent. Semantics
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