Isn't it nice when you have peace about a decision. That means it's the right one for you.
I agonized over this same question and finally decided on a shop in town, after a couple of years of contemplation. My kids are bigger now, which changes everything. I wouldn't ever work away from home when they were smaller, but now they're in middle school and much more self-sufficient, and they're used to me always working from home, either doing medical transcription or running my DH's business.
We had decided to go ahead and build on our property this year, and as we were looking into it (my b.i.l. is a realtor, which really helps), a brand-new retail location about 10 minutes from here turned up, ready to build to suit, with really great terms, in a beautiful perfect spot for what I need. The whole thing is falling together perfectly, so I know this is the right decision now, though at first I wasn't ready to consider working 'somewhere else', and I'm still sort of in shock that it's Really Happening...but it's growing on me.
Since DH and I work together running his business already, we have gotten very good at juggling business requirements and stinkin' long hours, and we are good at keeping "work" out of our family time, which can take some doing--you have to be able to work together and still have a marriage that doesn't include a business meeting in every conversation...
which we do. He keeps asking me if I know what I'm committing myself to, and I say, "I do....do YOU?" He's used to me always being here managing the entire household and our business, so I have to keep telling him that there will be times when *I* am not available because *I'm* at work...sorta like the 2 and 3 and 4 a.m. cake decorating marathons, only --hopefully-- it won't be as long or as late with the new ovens at the shop. (cross fingers)
You'll love having a place at home to go and work. Keep us posted on your progress, and best of luck!