I have read on this site that the sugar in the cream cheese frosting "stabilizes" it. I can say from personal experience, I have done red velvet cake & cupcakes and they've sat out for hours with no problem. I made pumpkin cupcakes with cream cheese frosting for Thanksgiving and they sat out for about 6 hours. My family ate them up with no problems or complaints. I use the Decorator Ceam Cheese frosting recipe from this site, it's yummy! HTH!