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What ever you try, remember that it is only cake. As long as you select a cake and icing you like, even if it turns out "less that beautiful" it will still taste great
Since it is your first decorated cake, I would do something simple, yet elegant.
For a fall/Thanksgiving theme, you could frost a cake in chocolate icing with chocolate shell borders then place silk fall covered leaves on the top and maybe draping down the sides.
I don't know your skill level, so I don't know how much to help with. Have you already learned the basics using the decorating tips and bags? Or will you be self-teaching yourself throughout this specific experience?
Another fun and easy idea would be to attach kit-kat bars to the outside of the cake and fill the top of the cake with the candy pumpkins and candy corn.
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